007: Blood Stone is the second Bond title produced by Activision after acquiring the well-known licence. It isn't based on any of the Bond novels or movies and thus features an original story. It is the first Bond title since 007: Everything or Nothing to do so.

Gameplay-wise it is a third-person shooter with elements of hand-to-hand combat. Also, there are some driving sequences. The game features a focus aim system which allows players to lock onto targets after melee takedowns, not too dissimilar to the "Mark and Execute" feature from Tom Clancy's Splinter Cell: Conviction.

There is also a multiplayer mode consisting of up to 16 players that will pit spies versus mercenaries. Alongside team deathmatch and other standard game modes there are massive objective-based battles where players have to work as a team to attack or defend various spy-themed goals. The player also pilots several vehicle types throughout the course of the game.